Insulin-Based Regulation of Glucose-functionalized Nanoparticle Uptake in Muscle Cells.
نویسندگان
چکیده
Effective regulation of nanoparticle (NP) uptake facilitates the NP-based therapeutics and diagnostics. Here, we report the use of insulin and 2-deoxyglucose (2-DG) to modulate the cellular uptake of glucose-functionalized quantum dots (Glc-QDs) in C2C12 muscle cells. The cellular uptake of Glc-QDs can be modulated up to almost two-fold under insulin stimulation while be down-regulated in the presence of 2-DG. These results demonstrate the use of secondary regulators to control the cellular uptake of NPs through membrane protein recognition in a specific and fine-tunable fashion.
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ورودعنوان ژورنال:
- Journal of materials chemistry. B
دوره شماره
صفحات -
تاریخ انتشار 2014